货号：02-415780
中文名称：（4s，7r，8s，9s，13z，16s）-4,8-双[叔丁基（二甲基）硅烷基]氧基-5,5,7,9,13-五甲基-16-[（e）-1-甲基-2-（2-甲基-1,3-噻唑-4-基）乙烯基]氧代环己烷-13-烯-2,6-二酮
英文名称：(3S,5S)-3,5-Bis(tert-butyldimethylsilyloxy)-2-methylene-cyclohexanone
CAS号：189453-35-8
重量：0.1mg
重量：1mg
分子式：C39H69NO5SSi2
别名：[4S-[4R*,7S*,8R*,9R*,13Z,16R*(E)]]-4,8-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,5,7,9,13-pentamethyl-16-[1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione;
应用介绍：An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers.